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September 10, 2025Non-Coding RNAOpen Access

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR

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Authors

STShohei TakaokaMJMarcos E. Jaso-VeraXRXiangbo Ruan

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Overview

Chimeric humanized liver mouse model reveals HuR suppresses fatty acid catabolism, highlighting gene regulation differences.

Key Points

  • HuR suppresses fatty acid catabolism in human hepatocytes, not in mouse models.
  • Blocking HuR leads to upregulation of fatty acid catabolism genes in human cells.
  • Pre-mRNA processing of fatty acid catabolism genes is impaired in humans, indicating a species difference.
  • HuR's regulation operates independently of PPARα expression and its role in mRNA stability.

Cite This Study

Takaoka et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d64780f9dhttps://doi.org/10.3390/ncrna11050065
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