August 17, 2025Open Access

The RNA-Binding Protein HuR Regulates Splicing Programs in Osteocytes

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Investigation reveals HuR regulates alternative splicing and gene expression in osteocytes, highlighting implications for hyperglycemia.

HuR knockdown significantly affects gene expression and mRNA splicing changes under high glucose stress, limiting cell viability.
Primary osteocytes exposed to high glucose show reduced HuR mRNA levels but unchanged protein levels, indicating a regulatory mechanism.
Analysis utilizing RNA-seq data identified HuR as a critical post-transcriptional regulator involved in insulin signaling pathways.
Findings suggest HuR plays a vital role in managing osteocyte adaptation to hyperglycemia, contributing to bone health.

Fan et al. (2025) studied this question.

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August 17, 2025Open Access

View Full Paper

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Authors

Investigation reveals HuR regulates alternative splicing and gene expression in osteocytes, highlighting implications for hyperglycemia.

HuR knockdown significantly affects gene expression and mRNA splicing changes under high glucose stress, limiting cell viability.
Primary osteocytes exposed to high glucose show reduced HuR mRNA levels but unchanged protein levels, indicating a regulatory mechanism.
Analysis utilizing RNA-seq data identified HuR as a critical post-transcriptional regulator involved in insulin signaling pathways.
Findings suggest HuR plays a vital role in managing osteocyte adaptation to hyperglycemia, contributing to bone health.

Fan et al. (2025) studied this question.

View Full Paper

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Bookmark