August 21, 2025BiomoleculesOpen Access

Integrated Multi-Omics Investigation of Gypenosides’ Mechanisms in Lowering Hepatic Cholesterol

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Gypenosides significantly restore expression levels of 42 genes and 14 proteins related to cholesterol regulation in the liver, impacting overall cholesterol levels.
Incorporating transcriptomics and proteomics, the study reveals critical gene interactions, with seven key proteins being consistently regulated by gypenosides.
High-fat diets caused notable changes in 48 genes influencing steroidogenesis, demonstrating the impact of diet on cholesterol homeostasis.
Findings indicate gypenosides downregulate key enzymes and enhance cholesterol transport, supporting their potential as a therapeutic agent against hypercholesterolemia.

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Integrated multi-omics analysis reveals gypenosides effectively lower cholesterol in hypercholesterolemic mice, suggesting new treatment avenues.

Jiang et al. (2025) studied this question.

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Integrated multi-omics analysis reveals gypenosides effectively lower cholesterol in hypercholesterolemic mice, suggesting new treatment avenues.