Integrated metabolomics and network pharmacology to investigate the anti-hyperlipidemia effect of geniposidic acid on high-fat diet induced mice

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Integrated analysis demonstrates lipid-lowering effects of geniposidic acid in hyperlipidemic mice, indicating potential therapeutic pathways.

Geniposidic acid significantly reduced lipid levels in hyperlipidemic mice, confirming its anti-hyperlipidemic efficacy.
Analysis identified over 40 differential metabolites and enriched metabolic pathways, revealing mechanisms behind GPA's effects.
Molecular docking showed that GPA interacts strongly with core proteins, suggesting they are potential therapeutic targets.
Findings advocate for further exploration of GPA as a promising agent for treating hyperlipidemia.

Tang et al. (2025) studied this question.

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Integrated analysis demonstrates lipid-lowering effects of geniposidic acid in hyperlipidemic mice, indicating potential therapeutic pathways.