September 10, 2025Scientific ReportsOpen Access

Comprehensive multiomics profiling reveals the protective function of gypenosides against dextran sulfate sodium-induced colitis

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Gypenosides significantly alleviate symptoms of colitis in a DSS-induced mouse model.
Treatment resulted in reduced colon shortening and lower disease activity index (DAI).
Multiomics profiling including transcriptomics and metabolomics uncovered critical metabolic pathways involved.
Findings suggest gypenosides enhance stem cell activity and promote mucosal repair through metabolic regulation.

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Observational analysis demonstrates the impact of gypenosides on ulcerative colitis, indicating their therapeutic potential.

Yang et al. (2025) studied this question.

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