Gypenosides Ameliorate Hyperlipidemia by Activating Lipophagy through Modulation of the AMPK/mTOR/ULK1 Signaling Pathway

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Gypenosides significantly reduced hepatic lipid content and alleviated hepatic steatosis in hamsters.
LDL-C levels were effectively lowered through lipophagy activation mediated by AMPK/mTOR/ULK1 pathways.
Assessment involved high-fat diet-fed golden Syrian hamsters and HepG2 cell models for lipid metabolism.
The findings support gypenosides as a natural alternative to enhance lipid reduction in hyperlipidemia patients.

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Clinical research finds gypenosides reduce LDL-C levels in hyperlipidemia, suggesting enhanced lipid metabolism.

Zhang et al. (2025) studied this question.

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