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August 21, 2025International Journal of Molecular SciencesOpen Access

Identification of Non-Invasive Diagnostic Markers for Oral Squamous Cell Carcinoma Through Salivary Microbiome and Gene Expression Analysis

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Authors

MHMitsuhiro HishidaKNKosuke NomotoKHK Hashimoto

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Overview

Analysis reveals diagnostic markers for oral squamous cell carcinoma through salivary microbiome and gene expression.

Key Points

  • Testing showed a high diagnostic accuracy for identifying early oral squamous cell carcinoma, improving potential treatment options.
  • In the OSCC group, microbiome analysis showed increased Fusobacterium and decreased Streptococcus, supporting specific microbial changes.
  • Gene expression analysis found that NUS1, RCN1, CPLANE1, and CCL20 were upregulated, indicating their relevance in OSCC's pathology.
  • Early detection through saliva analysis may improve patient outcomes, calling for more investigations in larger cohorts.

Cite This Study

Hishida et al. (2025) studied this question.

synapsesocial.com/papers/68af736e7567bf4f94fedbbahttps://doi.org/10.3390/ijms26168104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a Novel Salivary Four-miRNA Signature for Non-Invasive Diagnosis of Oral Squamous Cell Carcinoma2025
  2. 2Salivary Exosomal MicroRNAs as Non-Invasive Biomarkers for Early Detection of Oral Squamous Cell Carcinoma: A Prospective Diagnostic Study2025
  3. 3Biomarkers in oral squamous cell carcinoma: a systematic review.2025
  4. 4Identification of Potential Salivary Biomarkers and Enriched Protein Domain/Motif Families for Early Detection and Lymph Node Invasion in OSCC Patients of the Indian Population2025
  5. 5Salivaomic Biomarkers—An Innovative Approach to the Diagnosis, Treatment, and Prognosis of Oral Cancer2025 · 9 citations