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August 16, 2025

Biomarkers in oral squamous cell carcinoma: a systematic review.

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Authors

MLM.P. Lopez-GalindoMRMargaux Roques

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Overview

Systematic review identifies critical biomarkers for OSCC diagnosis and prognosis, suggesting enhanced clinical management.

Key Points

  • Identification of biomarkers improves the diagnostic accuracy for oral squamous cell carcinoma, enabling early detection and targeted treatment.
  • Saliva-based biomarkers demonstrate high sensitivity and specificity, providing a non-invasive option for early OSCC detection, essential for patient prognosis.
  • The study reviews 10 publications involving 1024 patients, highlighting the significance of biomarkers like Ki67 and PD-L1 linked to tumor progression.
  • Integration of biomarkers with TNM staging can personalize treatment approaches, though multicenter validation is needed for clinical adoption.

Cite This Study

Lopez-Galindo et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e58e7https://doi.org/10.4317/medoral.27565
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Salivaomic Biomarkers—An Innovative Approach to the Diagnosis, Treatment, and Prognosis of Oral Cancer2025 · 9 citations
  2. 2Exploring Metabolic and Immunological Biomarkers for Oral Squamous Cell Carcinoma: Potential Targets for Precision Therapy2025
  3. 3Immunohistochemical Markers in the Early Identification of Oral Squamous Cell Carcinoma: A Systematic Review2025
  4. 4Identification of Potential Salivary Biomarkers and Enriched Protein Domain/Motif Families for Early Detection and Lymph Node Invasion in OSCC Patients of the Indian Population2025
  5. 5Identification of Non-Invasive Diagnostic Markers for Oral Squamous Cell Carcinoma Through Salivary Microbiome and Gene Expression Analysis2025