Salivary Exosomal MicroRNAs as Non-Invasive Biomarkers for Early Detection of Oral Squamous Cell Carcinoma: A Prospective Diagnostic Study

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Prospective diagnostic study shows salivary exosomal miRNAs accurately detect early OSCC, suggesting non-invasive screening viability.

Salivary exosomal microRNAs accurately detected early-stage OSCC, with a combined panel achieving an AUC of 0.93.
The study involved 140 participants, including 60 OSCC patients, showing significant elevations in all tested miRNAs.
Saliva samples were analyzed for miRNA levels using qRT-PCR, corroborated by NTA, TEM, and Western blot methodologies.
High diagnostic accuracy supports integration of salivary exosomal microRNAs into routine cancer screening and surveillance.

Manal Mohammed Ahmad Al Muzeal (2025) studied this question.

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