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September 18, 2025Aging CellOpen Access

Alpha‐Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease

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Authors

SNSheeja NavakkodeBKBrian K. Kennedy

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Overview

Observational analysis reveals that alpha-ketoglutarate enhances synaptic plasticity in APP/PS1 mice, suggesting neuroprotective potential for Alzheimer's Disease.

Key Points

  • Alpha-ketoglutarate improves long-term potentiation deficits in APP/PS1 mice, particularly in females.
  • Treatment with calcium alpha-ketoglutarate increased LC3-II levels, indicating enhanced autophagy in AD mice.
  • CaAKG facilitates synaptic tagging and capture, showing promise for enhancing associative memory.
  • Rapamycin also rescued LTP in AD mice, highlighting the importance of autophagy in neuroprotection.

Cite This Study

Navakkode et al. (2025) studied this question.

synapsesocial.com/papers/68d434d6713b0b5dfea73cfehttps://doi.org/10.1111/acel.70235
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