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August 20, 2025Phytotherapy Research

Atractylenolide III Mitigates Alzheimer's Disease by Enhancing Autophagy via the YY1‐TFEB Pathway

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Authors

XZXiaowei ZhangSCShuang ChuYHYanli Huang

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Overview

Atractylenolide III improves cognitive function in Alzheimer's models, indicating its role in autophagy modulation via YY1 and TFEB.

Key Points

  • Atractylenolide III reduces amyloid protein deposition and alleviates cognitive decline in Alzheimer's models.
  • In APP/PS1 mice, AT-III enhanced learning and memory alongside increased TFEB activity and autophagy.
  • Observational analysis showed that AT-III stimulates the YY1-TFEB pathway, crucial for autophagy regulation.
  • Enhancing autophagy might offer a potential therapeutic target for Alzheimer's disease intervention.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af751a7567bf4f94fee2dehttps://doi.org/10.1002/ptr.70069
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