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August 21, 2025Frontiers in NutritionOpen Access

Associations of metabolic heterogeneity of obesity with the progression of cardiometabolic multimorbidity—a nationwide prospective cohort study

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Authors

NCNa CaiLZLin ZhangSDShuai Ding

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Overview

Longitudinal cohort study shows worsening metabolic health accelerates cardiometabolic multimorbidity risk in adults, highlighting the role of metabolic status.

Key Points

  • Metabolic health significantly increases the risk of cardiometabolic multimorbidity (CMM), with obese individuals facing the highest risk.
  • Among 5,850 participants, 562 (11.15%) developed CMM, with metabolically unhealthy obesity exhibiting a notable 3.31 odds ratio risk.
  • This longitudinal cohort study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) to explore BMI-metabolic phenotype changes.
  • The findings support personalized obesity management strategies based on metabolic health to mitigate CMM risk.

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/68af70627567bf4f94feb851https://doi.org/10.3389/fnut.2025.1617929
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio–Renal–Metabolic Multimorbidity: Tehran Lipid and Glucose Study2025
  2. 2Associations between metabolic heterogeneity of obesity and osteoarthritis: A prospective cohort study2025
  3. 3Association of Childhood Obesity Phenotypes With Cardiometabolic Outcomes in Adulthood: A Systematic Review and Meta‐Analysis2025
  4. 4Associations of metabolic heterogeneity of obesity, cardiometabolic index with sleep trajectory among middle-aged and older adults: a longitudinal study2025
  5. 5The association between baseline and long-term status of metabolic score for insulin resistance index and the incidence of cardiometabolic multimorbidity2025