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September 10, 2025Open Access

Associations between metabolic heterogeneity of obesity and osteoarthritis: A prospective cohort study

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Authors

HZHao ZhangMZMuhui ZengHYHao Yang

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Overview

Prospective cohort study examines how metabolic heterogeneity of obesity affects osteoarthritis risk, suggesting metabolic health is crucial.

Key Points

  • Higher obesity-related metabolic dysfunction correlates with increased osteoarthritis risk, especially in weight-bearing joints.
  • In the cohort of 381,036 participants, distinct obesity phenotypes showed varied risks for developing osteoarthritis.
  • Cox proportional hazards models indicated metabolic factors are significant mediators in the obesity-osteoarthritis relationship.
  • Promoting metabolic health could mitigate osteoarthritis risk across different obesity phenotypes.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d6478591fhttps://doi.org/10.1101/2025.09.02.25334896
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