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September 5, 2025Journal of the American Heart AssociationOpen Access

Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio–Renal–Metabolic Multimorbidity: Tehran Lipid and Glucose Study

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Authors

DMDanial MolavizadehSMSoroush MasrouriFEFarzad Esmaeili

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Overview

Observational analysis found varied CRM multimorbidity risk across different obesity phenotypes, highlighting significant associations.

Key Points

  • Participants with metabolically unhealthy obese phenotype showed the highest risk of CRM multimorbidity.
  • Compared to metabolically healthy normal weight, those with metabolically unhealthy overweight had a hazard ratio of 2.83.
  • Multivariable Cox regression models revealed increased risks for several obesity phenotypes affecting CRM health.
  • Findings suggest that beyond metabolically healthy normal weight, no benign obesity phenotype exists for CRM multimorbidity.

Cite This Study

Molavizadeh et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d348https://doi.org/10.1161/jaha.124.040930
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