The association between baseline and long-term status of metabolic score for insulin resistance index and the incidence of cardiometabolic multimorbidity
Cohort study evaluates the link between METS-IR and cardiometabolic multimorbidity incidence, suggesting higher risk with increased METS-IR exposure duration.
Key Points
Elevated baseline METS-IR is linked to a higher incidence of cardiometabolic multimorbidity (CMM).
Participants in the highest tertile of updated mean METS-IR had a 3.26 times increased risk of CMM.
Long-term METS-IR exposure showed a linear association with CMM, indicating consistent risk over time.
540 out of 8,050 participants developed CMM, highlighting significant health implications for midlife and older individuals.