Investigation reveals flavonols inhibit amyloid‐β and reduce oxidative stress in Alzheimer's disease, suggesting new treatment strategies.
Key Points
Flavonols effectively inhibit amyloid‐β aggregation and reduce oxidative stress, highlighting their multi-targeted therapeutic potential.
Quercetin shows neuroprotective effects by activating TrkB signaling and reducing tau phosphorylation, improving synaptic plasticity.
Kaempferol prevents Aβ-induced apoptosis via the ER/ERK/MAPK pathway, while myricetin ameliorates mitochondrial dysfunction and oxidative damage.
Overall, flavonols present low toxicity profiles and the ability to cross the blood-brain barrier, making them promising candidates for Alzheimer's treatment.