August 19, 2025Advanced ScienceOpen Access

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

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Authors

JZJianfeng ZhangCommercial Aircraft Corporation of China (China)JLJianchun LiUniversity of Technology Sydney QWQunyi Wang

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Implication

Observational analysis reveals neoeriocitrin boosts osteogenic differentiation in human dental pulp stem cells, indicating its potential in bone regeneration strategies.

Key Points

Neoeriocitrin significantly enhances osteogenic differentiation in human dental pulp stem cells, promoting bone regeneration.
Cellular thermal shift assay demonstrated that neoeriocitrin stabilizes Beclin1 by inhibiting its ubiquitination.
The study utilized an in vivo rat model, revealing that neoeriocitrin facilitates bone healing in calvarial defects.
These findings highlight potential new strategies for enhancing bone regeneration through modulation of autophagy.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af408ecf1dd9ea359ec25d https://doi.org/10.1002/advs.202504378

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Implication

Observational analysis reveals neoeriocitrin boosts osteogenic differentiation in human dental pulp stem cells, indicating its potential in bone regeneration strategies.

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

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Member takes

Implication

Key Points

Cite This Study

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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