September 10, 2025

Osteogenic potential of human dental pulp stem cells, and human dermal fibroblasts exposed hydroxyapatite nanoparticles: A comparative in vitro study.

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Authors

MNMohsen NaseriBirjand University of Medical Sciences SSSepideh SarfiBirjand University of Medical Sciences MHMohammad Yahya Hanafi‐Bojd

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Implication

In vitro analysis reveals osteogenic enhancement in human dental pulp stem cells and dermal fibroblasts with hydroxyapatite nanoparticles, suggesting implications for bone regeneration.

Key Points

Both human dental pulp stem cells and human dermal fibroblasts showed increased osteogenic potential after exposure to hydroxyapatite nanoparticles.
Cell viability was significantly assessed using an MTT assay at 24 and 72 hours of exposure, with positive results.
Gene expression analysis indicated up-regulation of osteogenic markers BMP-2 and VEGF-A in both cell types following hydroxyapatite nanoparticle exposure.
Findings suggest that while fibroblasts showed some mineralization potential, human dental pulp stem cells are more suitable for bone regenerative applications.

Cite This Study

Naseri et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a209d https://doi.org/10.22088/ijmcm.bums.14.2.656

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Implication

In vitro analysis reveals osteogenic enhancement in human dental pulp stem cells and dermal fibroblasts with hydroxyapatite nanoparticles, suggesting implications for bone regeneration.

Osteogenic potential of human dental pulp stem cells, and human dermal fibroblasts exposed hydroxyapatite nanoparticles: A comparative in vitro study.

Discussion

Member takes

Implication

Key Points

Cite This Study

Osteogenic potential of human dental pulp stem cells, and human dermal fibroblasts exposed hydroxyapatite nanoparticles: A comparative in vitro study.

Discussion

Member takes

Implication

Key Points

Cite This Study

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