September 10, 2025PLoS ONEOpen Access

Neuronal differentiation of human dental pulp stem cells induced by co-treatment of ergothioneine

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Discussion

Co-treatment with ergothioneine improves neuronal differentiation and neurogenic maturation in hDPSCs, indicating potential therapeutic uses.

Co-treatment of ergothioneine significantly enhances neuronal differentiation in human dental pulp stem cells.
Previous studies confirmed that the optimal concentration of ergothioneine for hDPSCs is 500 µM, leading to a high yield of neuronal-like cells.
The method used involved assessing cell viability, neuronal phenotypes via immunofluorescence, and intracellular calcium signaling.
These findings support the potential of ergothioneine as a therapeutic agent in stem cell-based treatments for neurological diseases.

Thongsuk et al. (2025) studied this question.

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Co-treatment with ergothioneine improves neuronal differentiation and neurogenic maturation in hDPSCs, indicating potential therapeutic uses.