September 10, 2025Open Access

Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

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This analysis shows enhanced neurotrophic factors in early-passage dental pulp stem cells, suggesting potential for nerve repair.

Neurodifferentiated hDPSCs at early passages secreted higher levels of neurotrophic factors, indicating effective nerve repair capabilities.
Exosomes from early-passage undifferentiated hDPSCs contained a relevant neuroregenerative mRNA cargo crucial for tissue recovery.
Multiplex immunoassays and RT-PCR demonstrated changes in secretory profiles across different passages of hDPSCs.
Findings highlight the potential of early-passage hDPSCs in a nerve repair context for use in cell-free therapies.

Lopes et al. (2025) studied this question.

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