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August 14, 2025Tumor DiscoveryOpen Access

Convergence of epithelial-mesenchymal transition and mitochondrial dynamics: Mechanisms and therapeutic opportunities in cancer metastasis

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Authors

HDHarsh DaveBPBinita PatelKJKaid Johar

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Overview

This review uncovers the link between mitochondrial dynamics and epithelial-mesenchymal transition in cancer metastasis, suggesting new therapeutic targets.

Key Points

  • The interplay between mitochondrial dynamics and epithelial-mesenchymal transition significantly impacts cancer metastasis, suggesting potential therapeutic strategies.
  • Dysregulation in mitochondrial dynamics can drive cancer progression through altered energy metabolism and cell signaling pathways.
  • This review highlights emerging insights into how mitochondrial fusion and fission contribute to EMT's metabolic shifts in cancer cells.
  • Understanding the relationship between EMT and mitochondrial dynamics may reveal critical targets for fibrosis and cancer therapies.

Cite This Study

Dave et al. (2025) studied this question.

synapsesocial.com/papers/68af3e3ccf1dd9ea359eb056https://doi.org/10.36922/td025160029
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epithelial-mesenchymal dynamics in cancer: Role of signalling pathways, stromal interactions and natural therapies2025 · 3 citations
  2. 2Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases2025
  3. 3Mitochondria and Tumorigenesis2025
  4. 4Mitochondrial metabolism and cancer therapeutic innovation2025
  5. 5The Diverse Roles of Mitochondria in Regulating Cancer Metastasis2025 · 7 citations