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October 1, 2025International Journal of Molecular SciencesOpen Access

Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases

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Authors

VBVíctor Alexandre Félix BastosASAline Gomes de SouzaVGVirginia C. Silvestrini Guedes

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Overview

This review highlights shared mechanisms of EMT within cancer and fibrotic diseases, suggesting innovative therapeutic targets.

Key Points

  • EMT promotes tumor progression and fibrotic remodeling, impacting invasion and therapy resistance.
  • Shared mechanisms in cancer and fibrosis involve signaling pathways like TGF-β and transcription factors such as SNAIL.
  • Partial EMT contributes to fibroblast activation and excessive extracellular matrix deposition in various organs.
  • Single-cell transcriptomics and lineage tracing are revolutionizing our understanding of EMT across different diseases.

Cite This Study

Bastos et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc4992cchttps://doi.org/10.3390/ijms26199476
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