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September 10, 2025ADMET & DMPKOpen Access

Epithelial-mesenchymal dynamics in cancer: Role of signalling pathways, stromal interactions and natural therapies

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Authors

SSSiddharth SinghIKIram KhanABAnindita Behera

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Overview

This review discusses metastasis and signalling pathways in cancer, highlighting natural therapies' potential.

Key Points

  • Epithelial-mesenchymal transition is crucial in cancer progression, contributing to metastasis and drug resistance.
  • Therapeutic molecules from plants and animals, such as ginseng and bee venom, show promise in targeting EMT pathways.
  • Key findings highlight the role of p53 in EMT, impacting cancer metastasis and treatment outcomes.
  • Emerging natural compounds from marine sources exhibit significant anti-metastatic effects by regulating EMT.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c653https://doi.org/10.5599/admet.2836
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Research on Tumor Drug Resistance Mediated by Epithelial-mesenchymal Transition2025
  2. 2Epithelial–Mesenchymal Transition in Cancer: Insights Into Therapeutic Targets and Clinical Implications2025
  3. 3Convergence of epithelial-mesenchymal transition and mitochondrial dynamics: Mechanisms and therapeutic opportunities in cancer metastasis2025
  4. 4Insights into the Molecular Mechanisms and Signaling Pathways of Epithelial to Mesenchymal Transition (EMT) in the Pathophysiology of Endometriosis2025
  5. 5Deciphering molecular pathways driving cancer invasion and metastasis: advances and therapeutic prospects2025