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August 19, 2025Journal of Clinical InvestigationOpen Access

Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy

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Authors

DTDiana Tavares‐FerreiraBSBreanna Q. ShenJMJuliet M. Mwirigi

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Overview

Analysis identifies inflammatory activation and immune shifts in peripheral nerves of diabetic patients, suggesting early nerve degeneration.

Key Points

  • Inflammatory activation occurs in diabetic peripheral neuropathy nerves, contributing to sensory changes.
  • Transcriptomic analysis revealed distinct immunological features and neuronal transcript changes in affected nerves.
  • Spatial transcriptomics showed shifts in immune cell types linked to axonal loss progression in diabetic nerve tissues.
  • Findings indicate that mRNA localization in sensory axons may play a role in nerve degeneration in diabetic peripheral neuropathy.

Cite This Study

Tavares‐Ferreira et al. (2025) studied this question.

synapsesocial.com/papers/68af35e3cf1dd9ea359ea11chttps://doi.org/10.1172/jci184075
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