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September 10, 2025Nature CommunicationsOpen Access

Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

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Authors

MHMichael HemingABAnna‐Lena BörschJWJolien Wolbert

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Overview

Integrated transcriptomics revealed nerve cell marker changes in polyneuropathies, highlighting diagnostic potential.

Key Points

  • Nerve biopsies revealed shared changes across polyneuropathies, indicating a loss of myelinating Schwann cells.
  • Unexpected heterogeneity in perineurial cells was uncovered, including increased lipid-associated macrophages.
  • Single-nucleus transcriptomics and spatial transcriptomics were utilized to analyze tissues from 33 PNP patients.
  • Findings suggest polyneuropathies may be viewed as 'pan-nerve diseases', highlighting the need for diagnostic advancements.

Cite This Study

Heming et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5494https://doi.org/10.1038/s41467-025-62964-8
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