Bidirectional MR examines connections between central nervous system dysfunction and diabetic peripheral neuropathy, suggesting new treatment approaches.
Key Points
Reduced connectivity in the default mode network elevates diabetic peripheral neuropathy risk, pointing to central nervous system involvement.
Causal analysis revealed significant relationships where DPN elevates subcortical-cerebellar hyperconnectivity, enhancing motor function stability.
Observational analysis using resting-state functional magnetic resonance imaging explored neural connectivity changes in various patient groups.
Findings highlight the need for new circuit-targeted therapies, redefining diabetic peripheral neuropathy beyond peripheral neurodegeneration.