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July 22, 2025MedicineOpen Access

Mitochondrial dynamics in diabetic peripheral neuropathy: Pathogenesis, progression, and therapeutic approaches

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Authors

HYHaiying YuCYCunqing YangGWGuoqiang Wang

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Overview

Research demonstrates mitochondrial dynamics influence disease progression in patients with DPN, indicating potential new treatment pathways.

Key Points

  • Mitochondrial dynamics play a critical role in the pathogenesis of diabetic peripheral neuropathy (DPN).
  • Dysregulation of fission and fusion proteins contributes to bioenergetic dysfunction in neurons under high glucose levels.
  • Mitochondrial alterations are linked to inflammation, energy production, and cell death in DPN patients.
  • Targeted therapies aimed at restoring mitochondrial function could lead to improved treatment options for DPN.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd70ehttps://doi.org/10.1097/md.0000000000042748
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