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August 1, 2025Drug Design Development and TherapyOpen Access

Xian Huang Fang Inhibits the PKCδ/MAPK Signaling Pathway to Attenuate Renal Tubular Epithelial Cell Senescence and Thereby Delay Renal Interstitial Fibrosis

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Authors

WYWang YanruMSMinghai ShaoTLTingting Li

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Overview

Observational analysis revealed Xian Huang Fang improves renal interstitial fibrosis in CKD, indicating a protective mechanism through PKCδ inhibition.

Key Points

  • Xian Huang Fang significantly reduces renal interstitial fibrosis, alleviating renal injury in a chronic kidney disease model.
  • Analysis identified PKCδ as a key target with inhibition reducing p-p38, p-ERK, and p-JNK levels.
  • Assessment used various methods including Western blotting and immunofluorescence to evaluate cellular mechanisms.
  • Inhibiting PKCδ/MAPK highlights potential therapeutic avenues for chronic kidney disease progression.

Cite This Study

Yanru et al. (2025) studied this question.

synapsesocial.com/papers/68af268acf1dd9ea359e1bbdhttps://doi.org/10.2147/dddt.s522318
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