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September 25, 2025Frontiers in PharmacologyOpen Access

Integrated network pharmacology and experimental validation to investigate the therapeutic effects and mechanisms of SJZT on hypertensive nephropathy

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Authors

BCBin ChenGWGuanghui WangJZJianbo Zhou

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Overview

Preclinical analysis demonstrates how sijunzitang alleviates hypertensive nephropathy, indicating pparγ involvement.

Key Points

  • SJZT reduces renal damage and extracellular matrix deposition in hypertensive nephropathy model mice.
  • Network pharmacology identified 87 active components and 26 therapeutic targets for SJZT treatment.
  • SJZT activates autophagy through pparγ upregulation, suppressing renal fibroblast activation.
  • Application of SJZT offers new insights into hypertensive nephropathy treatment strategies.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1ffbd7882ccb9b8657ehttps://doi.org/10.3389/fphar.2025.1625482
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