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August 22, 2025International Journal of Basic & Clinical PharmacologyOpen Access

Potential restorative effect of silymarin on liver histoarchitecture on paracetamol-induced in hepatotoxicity, in adult albino rats

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Authors

DNDavis Kiprono NgetichMOM.W. Okoth

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Overview

Observational analysis showed histo-restoration in liver tissues of adult albino rats, indicating silymarin's protective role against paracetamol-induced damage.

Key Points

  • Silymarin significantly restored liver architecture after paracetamol-induced toxicity, improving overall liver health.
  • Histological examination revealed even distribution of hepatocytes and reduced damage to the central vein.
  • A randomized treatment protocol involved administering different doses of silymarin following paracetamol exposure.
  • These findings highlight the liver-protective properties of silymarin, suggesting its potential as a restorative agent.

Cite This Study

Ngetich et al. (2025) studied this question.

synapsesocial.com/papers/68af76ad7567bf4f94fef2d1https://doi.org/10.18203/2319-2003.ijbcp20252560
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