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August 11, 2025Hepatitis MonthlyOpen Access

Effects of Silymarin Combined with Herbal Medicine on Th17/Treg Cell Imbalance and Inflammatory Response in Patients with Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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Authors

MMMeiqing MaiYWYa WangDWDi Wang

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Overview

Randomized trial demonstrated reduced Th17/Treg imbalance and inflammation in NAFLD patients with silymarin and TCM, suggesting potential therapeutic benefits.

Key Points

  • Silymarin combined with traditional Chinese medicine significantly reduced IL-18 in NAFLD patients after 12 weeks.
  • The combination therapy decreased Th17 cell proportions and restored the Th17/Treg ratio in the treatment group.
  • This randomized, double-blind, placebo-controlled trial enrolled 94 NAFLD patients over 12 weeks.
  • The findings suggest that combining silymarin with TCM may provide a novel and effective approach to managing NAFLD.

Cite This Study

Mai et al. (2025) studied this question.

synapsesocial.com/papers/68af76bf7567bf4f94fefeefhttps://doi.org/10.5812/hepatmon-157416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications.2025
  2. 2Silymarin as a phytopharmaceutical agent: advances in mechanistic insights, formulation strategies, and pre-clinical applications2025 · 14 citations
  3. 3Exercise-Induced Increase in Serum Irisin Levels is Associated with Antioxidant Effects of Silymarin in Dexamethasone- Induced NAFLD2025
  4. 4Additive Effects of Mesenchymal Stem Cell-Conditioned Medium and Silymarin in Carbon Tetrachloride-Induced Liver Injury in Rats2025
  5. 5Cytoprotective Effect of Silymarin on Moxifloxacin-Induced Liver Toxicity: Investigation of ER Stress (PERK/ATF6/GRP78), Oxidative Stress (Nrf2/HO-1) and Apoptosis (Caspase-3/Bax/Bcl-2) Pathways2026