September 10, 2025Scientific ReportsOpen Access

AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway

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Investigating AMF30a's effects on TGF-β-induced oxidative stress in corneal endothelial cells reveals significant implications for cell survival.

AMF30a treatment significantly enhances cell viability and proliferation in corneal endothelial cells.
Transcriptome analysis revealed differentially expressed genes linked to TGF-β/ROCK/HIPPO signaling.
AMF30a mitigates TGF-β-induced oxidative stress and its harmful effects on cell functionality.
The findings support AMF30a's potential as a therapeutic strategy for corneal diseases through PAD2 inhibition.

Ryu et al. (2025) studied this question.

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Investigating AMF30a's effects on TGF-β-induced oxidative stress in corneal endothelial cells reveals significant implications for cell survival.