Protective Role of Cynara cardunculus L. var. altilis Against Oxidative Stress and Corneal Dysfunction in High Glucose-Damaged Human Corneal Epithelial Cells
Observational analysis shows CC extract reduces oxidative stress and improves corneal function in high glucose-treated human epithelial cells, indicating potential for diabetic care.
Key Points
CC leaf extract improved cell viability and reduced oxidative stress in human corneal epithelial cells exposed to high glucose concentrations.
The treatment elevated antioxidant activities of SOD and CAT, and increased GSH levels, while lowering reactive oxygen species production.
CC extract maintained high transepithelial electrical resistance and promoted wound healing in corneal epithelial cells affected by hyperglycemia.
Down-regulation of ERK1/2/cPLA2/COX-2 signaling pathway was observed, which is involved in inflammation and oxidative stress response.