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August 16, 2025Journal of Proteome Research

Vitreous Olink Proteomics Uncovers Novel Inflammatory Proteins in Patients with Proliferative Diabetic Retinopathy

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Authors

JZJiayu ZhangYWYimin WangXWXinyuan Wu

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Overview

Analysis reveals heightened inflammatory cytokines and FGF23 in proliferative diabetic retinopathy, suggesting new treatment routes.

Key Points

  • Individuals with proliferative diabetic retinopathy showed significantly elevated concentrations of inflammatory cytokines, indicating inflammation's role in the disease.
  • A total of 22 differentially expressed proteins were identified, with 21 proteins increased, highlighting a strong inflammatory response in PDR patients.
  • Using Olink proteomics, the study compared 92 inflammatory cytokines between PDR patients and control subjects diagnosed with idiopathic macular hole.
  • FGF23 was identified as a promising candidate that may play a critical role in promoting angiogenesis under hyperglycemic conditions.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af2b68cf1dd9ea359e4d4chttps://doi.org/10.1021/acs.jproteome.5c00394
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combined proteomics and metabolomics analyses revealed molecular signatures associated with proliferative diabetic retinopathy2025
  2. 2Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction2025
  3. 3A key role of the PGC-1α/ERR-α pathway in regulation of angiogenic factors in proliferative diabetic retinopathy2025
  4. 4Assessment of causality between circulating inflammatory proteins and subtypes of diabetic retinopathy2025
  5. 5Lipidomic analysis of vitreous humor derived from patients with proliferative diabetic retinopathy2025