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October 23, 2025Signal Transduction and Targeted TherapyOpen Access

Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction

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Authors

MMMaximilian McCannBBBasma BaccoucheYLYueru Li

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Overview

Analysis reveals distinct proliferative diabetic retinopathy types characterized by immune and endothelial cell differences, suggesting new therapeutic targets.

Key Points

  • Pathological angiogenesis is a key feature of diabetic retinopathy, leading to potential treatment strategies.
  • Endothelial cells were predominant in some patients, while immune cells and gene expression programs were highlighted in others.
  • Assessment indicated that preclinical testing via the murine oxygen-induced retinopathy model has limitations in understanding human PDR.
  • Anti-VEGF therapy impacts both endothelial and immune cells, offering insights into treatment implications.

Cite This Study

McCann et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74205ahttps://doi.org/10.1038/s41392-025-02448-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combined proteomics and metabolomics analyses revealed molecular signatures associated with proliferative diabetic retinopathy2025
  2. 2Vitreous Olink Proteomics Uncovers Novel Inflammatory Proteins in Patients with Proliferative Diabetic Retinopathy2025
  3. 3A key role of the PGC-1α/ERR-α pathway in regulation of angiogenic factors in proliferative diabetic retinopathy2025
  4. 4Artificial intelligence in proliferative diabetic retinopathy: advancing diagnosis, precision surgery, and anti-VEGF therapy optimization2025
  5. 5The Long-Standing Problem of Proliferative Retinopathies: Current Understanding and Critical Cues.2025