September 10, 2025Frontiers in EndocrinologyOpen Access

A key role of the PGC-1α/ERR-α pathway in regulation of angiogenic factors in proliferative diabetic retinopathy

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Discussion

Analysis reveals PGC-1α and ERR-α increase angiogenic factors in proliferative diabetic retinopathy, suggesting therapeutic targets.

Increased expression of PGC-1α and ERR-α correlates with angiogenic activity in proliferative diabetic retinopathy.
Western blot and ELISA analyses confirmed that VEGF and angiopoietin 2 levels were elevated in PDR vitreous fluid samples.
Rat model studies demonstrated that diabetes induces upregulation of PGC-1α and ERR-α in retinal tissues, linked to angiogenesis.
Inhibiting PGC-1α and ERR-α in Müller cells significantly reduced the upregulation of angiogenic markers under diabetic conditions.

El‐Asrar et al. (2025) studied this question.

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September 10, 2025Frontiers in EndocrinologyOpen Access

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Authors

Analysis reveals PGC-1α and ERR-α increase angiogenic factors in proliferative diabetic retinopathy, suggesting therapeutic targets.

Increased expression of PGC-1α and ERR-α correlates with angiogenic activity in proliferative diabetic retinopathy.
Western blot and ELISA analyses confirmed that VEGF and angiopoietin 2 levels were elevated in PDR vitreous fluid samples.
Rat model studies demonstrated that diabetes induces upregulation of PGC-1α and ERR-α in retinal tissues, linked to angiogenesis.
Inhibiting PGC-1α and ERR-α in Müller cells significantly reduced the upregulation of angiogenic markers under diabetic conditions.

El‐Asrar et al. (2025) studied this question.

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