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September 16, 2025International Journal of Ophthalmology

Assessment of causality between circulating inflammatory proteins and subtypes of diabetic retinopathy

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Authors

MDMin DongWCWeidong CaoXDXu Deng

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Implication

Mendelian randomization reveals associations between inflammatory proteins and diabetic retinopathy severities, suggesting therapeutic targets.

Key Points

  • Bi-directional Mendelian randomization analysis demonstrates a complex relationship between inflammatory proteins and diabetic retinopathy.
  • Elevated levels of specific proteins like IL-10 and VEGF-A are associated with reduced risk of non-proliferative diabetic retinopathy.
  • Key inflammatory factors like FGF-23 and Caspase 8 are linked to increased risks of different diabetic retinopathy subtypes.
  • Findings support the role of inflammatory factor dysregulation in diabetic retinopathy, highlighting potential immunotherapeutic strategies.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68d421aa713b0b5dfea6a7bchttps://doi.org/10.18240/ijo.2025.10.22
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