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October 9, 2025The Journal of Experimental MedicineOpen Access

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

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Authors

YXYan XuZZZheqi ZhouWCWen-Zheng Chen

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Overview

Study uncovers how TREX1 upregulation helps MSI-H tumors evade immunity, suggesting new immunotherapy strategies.

Key Points

  • dMMR tumors exploit TREX1 to evade immune response, allowing tumor growth.
  • Depletion of Trex1 in tumors eliminates formation through enhancing CD8+ T cell activity.
  • Targeting the cGAS–STING signaling pathway enhances immune response against MSI-H/dMMR tumors.
  • TREX1 inhibition can specifically reduce growth in MSI-H/dMMR tumors, highlighting clinical implications.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68e70da790569dd607ee59c3https://doi.org/10.1084/jem.20250265
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