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September 10, 2025Frontiers in ImmunologyOpen Access

Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance

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Authors

GMGuichuang MaXLXiaohan LiuQJQinrui Jiang

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Overview

Comprehensive analysis reveals CD8 T cells and macrophages driving immune resistance in gastric cancer.

Key Points

  • The study identifies a stromal immunosuppressive network that impedes antitumor immunity in gastric cancer.
  • Comprehensive profiling revealed 20 immune subsets, unveiling critical prognostic and therapeutic insights.
  • Using multi-omic approaches, the research highlights the role of macrophages and exhausted CD8 T cells in resistance.
  • Developing a TME classification system based on immune cell markers may enhance personalized immunotherapy strategies.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d647950a4https://doi.org/10.3389/fimmu.2025.1618591
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