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August 8, 2025Frontiers in ImmunologyOpen Access

B cell development: transcriptional regulation and immunological mechanisms in homeostasis

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Authors

JGJorge Gómez-ManríquezJHJorge Hernández‐BelloJMJosé Francisco Muñoz‐Valle

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Overview

Review highlights dysregulated B cell development and potential links to autoimmunity and malignancies.

Key Points

  • Dysregulated mechanisms can lead to autoimmunity or malignancies, impacting overall health.
  • Key transcriptional factors guide B cell maturation, influencing vital immune functions like antibody production.
  • Analysis of immunological tolerance in B lymphocytes reveals critical mechanisms for disease pathophysiology.
  • The comprehensive review stresses the importance of understanding these pathways as therapeutic targets.

Cite This Study

Gómez-Manríquez et al. (2025) studied this question.

synapsesocial.com/papers/68af2b63cf1dd9ea359e4b60https://doi.org/10.3389/fimmu.2025.1593338
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  4. 4Posttranscriptional control of the B cell receptor by HuR is essential for innate B cell maintenance and function.2025
  5. 5A Single-Cell Atlas of Transcriptional and Immunoglobulin Repertoire Evolution in Early B Cell Development2025