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September 10, 2025NatureOpen Access

TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function

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Authors

QSQian ShenShanghai Jiao Tong UniversityHWHao WangShanghai Ocean UniversityJRJonathan A. RocoAustralian National University

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Implication

Investigation shows TCF1 and LEF1 influence B-1a cell maintenance and regulatory roles, implying new insights into immune cell regulation.

Key Points

  • TCF1 and LEF1 are essential for maintaining B-1a cell homeostasis, revealing their importance in immune regulation.
  • Mice lacking TCF1 and LEF1 show a significant decrease in B-1a cells and present with an exhausted cell phenotype.
  • These transcription factors promote metabolic pathways and regulatory functions in B-1a cells, primarily through IL-10 production.
  • The role of TCF1 and LEF1 extends to human chronic lymphocytic leukaemia B cells, suggesting implications for immune disorders.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a489dhttps://doi.org/10.1038/s41586-025-09421-0
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