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June 28, 2026MedCommOpen Access

The Dual Roles of Regulatory B Cells in Infection, Cancer, and Immunity

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Authors

AFAnni FengQLQi LiNJNing Jiang

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Overview

This review examines the dual roles of regulatory B cells in infections and cancer, indicating their complex regulatory functions in immunity.

Key Points

  • The aim is to explore the dual roles of regulatory B cells in immune regulation across various clinical contexts.
  • Review of literature on regulatory B cells in infections, cancer, autoimmune disorders, and transplantation.
  • Analysis of cytokines and pathways involved in Bregs function.
  • Discussion of therapeutic potential in modulating Bregs activities.
  • Regulatory B cells protect against autoimmunity and promote transplant tolerance.
  • They can also enhance the progression of chronic infections and cancers by suppressing immune responses.
  • A functional dichotomy was identified, emphasizing the dual roles of Bregs in health and disease.

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/6a40bae361bb0a67205c6901https://doi.org/10.1002/mco2.70850
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