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October 10, 2025Open Access

A Single-Cell Atlas of Transcriptional and Immunoglobulin Repertoire Evolution in Early B Cell Development

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Authors

CDCharlotte N. DiBiaseScripps Research InstituteJHJonathan HurtadoScripps Research InstituteBBBryan S. BrineyScripps Research Institute

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Implication

This study reveals insights into b cell development and immunoglobulin repertoire evolution, suggesting novel pathways for further research.

Key Points

  • Substantial insights into b cell development were gained through single-cell rna sequencing of 65,110 cells, revealing functional diversity.
  • Analyses show proliferative bursts after heavy and light chain recombination, uncovering features not previously described in pro-B cells.
  • Changes in gene usage were prominent, highlighting a shortening of heavy chain cdr3s as b cells progressed through lymphopoiesis.
  • The findings underscore the role of early selection processes in shaping the immunoglobulin repertoire, indicating areas for future research.

Cite This Study

DiBiase et al. (2025) studied this question.

synapsesocial.com/papers/68e861857ef2f04ca37e3938https://doi.org/10.1101/2025.10.08.681095
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decoding human B cell ontogeny in prenatal and adult bone marrow and in vitro models via single-cell multiomics2025 · 2 citations
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  4. 4Inferring B Cell Phylogenies from Paired Heavy and Light Chain BCR Sequences with Dowser 90502025
  5. 5Naturally occurring polymorphisms reveal the cis-regulatory architecture priming marginal zone B cell differentiation 44672025