September 10, 2025

Palladium-Catalyzed Formal 3+2 Cycloadditions to Access Spirocyclopentane-2-oxindole Fused Chromanones, Quinolinones, and Thiochromones.

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Palladium-catalyzed cycloaddition provides spirooxindoles and analogues with high yields, suggesting synergy with greener solvents.

The cycloaddition reaction achieved up to 97% yields in product formation, with high diastereomeric ratios.
Utilization of inexpensive ligands and greener solvents improved the diastereocontrol of the resulting spirooxindole structures.
Broad substrate scope and potential synthetic transformations showcase the versatility and applicability of this method.
This approach bridges synthetic chemistry and medicinal applications, enhancing the development of bioactive molecules.

Nachimuthu et al. (2025) studied this question.

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