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January 1, 2025

CEP68/FLRT2: The Potential Druggable Genes For Atrial Fibrillation Identified By Systematic Druggable Genome-Wide Mendelian Randomization

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Authors

JZJiansuo ZhouHDHuan DongFLFeng Liu

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Overview

Mendelian randomization analysis finds 21 potential druggable genes linked to atrial fibrillation, suggesting new treatment options.

Key Points

  • Twenty-one druggable genes were identified as potential targets for atrial fibrillation, enhancing treatment strategies.
  • Among these genes, CEP68 and FLRT2 showed significant associations in cardiac and blood tissue analysis.
  • Our approach utilized Mendelian randomization and summary MR analyses to explore genetic influences on atrial fibrillation.
  • Results indicate that CEP68 was correlated with atrial fibrillation/flutter, providing further implications for drug development.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68af296ecf1dd9ea359e29e0https://doi.org/10.70374/amccr.2025.1701
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Also Consider

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  1. 1Single‐Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation2026
  2. 2Unraveling the Role of PTGIR in Atrial Fibrillation: Insights From Single‐Cell Sequencing and Mendelian Randomization2025
  3. 3Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome‐Wide Mendelian Randomization Analysis2025 · 1 citations
  4. 4Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies2025
  5. 5Identification of therapeutic targets for rheumatic heart valve disease based on systematic druggable genome wide Mendelian randomization2025