Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 30, 2025The FASEB JournalOpen Access

Unraveling the Role of PTGIR in Atrial Fibrillation: Insights From Single‐Cell Sequencing and Mendelian Randomization

View Full Paper
Ask AI
Bookmark
Share

Authors

ZLZhengyu LinYZYang ZouYCYuqi Chen

Discussion

Loading...

Member takes

Overview

Analysis uncovers protective and risk factors for atrial fibrillation using Mendelian randomization, highlighting molecular mechanisms in a rat model.

Key Points

  • Mendelian randomization identified protective factors like COL6A2 and PTGIR, aiding in understanding atrial fibrillation.
  • Risk factors such as SERPINE1 and VIM were highlighted, revealing complexity in atrial fibrillation pathogenesis.
  • This observational analysis involved single-cell RNA sequencing to analyze 47,565 cells from atrial fibrillation and control samples.
  • Findings suggest fibroblast-mediated mechanisms are critical in atrial fibrillation, with implications pointing to new therapeutic targets.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/692b9d831d383f2b2a3798f3https://doi.org/10.1096/fj.202501843rr
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single‐Cell Transcriptomics and Mendelian Randomization Analysis Reveal Key Genes in Atrial Fibrillation2026
  2. 2TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies2025 · 4 citations
  3. 3Cellular interactions and Ion channel signatures in atrial fibrillation remodeling: insights from single-cell analysis and machine learning2025 · 1 citations
  4. 4Single nucleus transcriptomics reveals ITGA8-driven fibroblast remodeling in rheumatic valvular atrial fibrillation2026
  5. 5CEP68/FLRT2: The Potential Druggable Genes For Atrial Fibrillation Identified By Systematic Druggable Genome-Wide Mendelian Randomization2025