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August 17, 2025World Journal of Experimental Medicine

Management of anticoagulation in patients with atrial fibrillation and renal dysfunction: A systematic review

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Authors

AKAnish KumarCKChander KumarAKAjay Kumar

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Overview

Systematic review provides guidance on anticoagulation strategies in patients with renal dysfunction, emphasizing the role of apixaban.

Key Points

  • Optimal anticoagulation reduces stroke risk in patients with atrial fibrillation and renal dysfunction, improving clinical outcomes.
  • Evidence recommends apixaban for moderate chronic kidney disease, balancing risks to minimize bleeding complications.
  • The systematic review assessed 16 studies, capturing renal function and anticoagulant dosing strategies providing valuable insights.
  • Quality assessments used Cochrane Risk of Bias tool, highlighting the need for individualized therapy in managing anticoagulation.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/68a35486234c60ad5c20eb6ahttps://doi.org/10.5493/wjem.v15.i3.105485
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction2020
  2. 2Comparative Efficacy and Safety of Novel Oral Anticoagulants in Atrial Fibrillation with Chronic Kidney Disease: A Systematic Review, Meta-Regression, and Network Meta-Analysis2025
  3. 3Oral anticoagulant therapy for patients with atrial fibrillation on long‐term dialysis: A network meta‐analysis of 137,574 patients2025 · 7 citations
  4. 4The prevalence and burden of chronic kidney disease, patterns of anticoagulation prescribing, and major bleeding risk in older adults with atrial fibrillation2025 · 1 citations
  5. 5The Renal Impact of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis2026