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October 10, 2025Russian Journal of CardiologyOpen Access

New aspects of anticoagulant therapy in atrial fibrillation in patients with renal dysfunction

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Authors

ЖКЖ. Д. КобалаваPLP. V. LazarevMVM. V. Vatsik

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Overview

This review highlights anticoagulant therapy differences in atrial fibrillation patients with renal dysfunction, indicating key safety and efficacy considerations.

Key Points

  • Safety and efficacy of direct oral anticoagulants may vary depending on renal function, impacting treatment choices.
  • Direct oral anticoagulants are compared against warfarin to assess effectiveness and risks in atrial fibrillation with chronic kidney disease.
  • Renal function assessment is crucial for optimizing anticoagulant therapy in patients with renal dysfunction and AF.
  • This review incorporates findings from randomized controlled trials and guidelines to address therapy in varying stages of renal dysfunction.

Cite This Study

Кобалава et al. (2020) studied this question.

synapsesocial.com/papers/68e8cbdd34f1e6a86e180c3chttps://doi.org/10.15829/1560-4071-2020-4175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of anticoagulation in patients with atrial fibrillation and renal dysfunction: A systematic review2025 · 2 citations
  2. 2Efficacy and safety of oral anticoagulants in the treatment of chronic kidney disease with atrial fibrillation or venous thromboembolism: a systematic review and meta-analysis2025 · 8 citations
  3. 3The Renal Impact of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis2026
  4. 4Comparative Efficacy and Safety of Novel Oral Anticoagulants in Atrial Fibrillation with Chronic Kidney Disease: A Systematic Review, Meta-Regression, and Network Meta-Analysis2025
  5. 5Comparative efficacy and safety of warfarin and direct oral anticoagulants in patients with end-stage renal disease and atrial fibrillation2026 · 1 citations