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September 10, 2025European Journal of Clinical Investigation

Oral anticoagulant therapy for patients with atrial fibrillation on long‐term dialysis: A network meta‐analysis of 137,574 patients

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Authors

YDYao DuYZYan-Mei ZengSXSixin Xu

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Overview

Network meta-analysis reveals OAC strategies do not reduce stroke risk in patients with AF on dialysis, suggesting apixaban may improve mortality.

Key Points

  • Apixaban 5 mg twice daily reduced all-cause mortality in patients with AF on dialysis compared to no OAC use.
  • No OACs significantly decreased the risk of ischaemic stroke compared with no anticoagulant therapy in this patient population.
  • Dabigatran and phenprocoumon were linked to a higher risk of major bleeding compared to non-OAC use.
  • The analysis incorporated 33 studies with a total of 137,574 patients, highlighting the urgent need for optimal treatment strategies.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478c6cahttps://doi.org/10.1111/eci.70120
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oral anticoagulation and left atrial appendage closure in dialysis atrial fibrillation: between stroke prevention and bleeding hazard2026
  2. 2Left Atrial Appendage Occlusion vs Anticoagulants in Dialysis With Atrial Fibrillation2025 · 10 citations
  3. 3Oral Anticoagulants in Patients With Atrial Fibrillation and Advanced CKD Not Requiring Dialysis2026
  4. 4Management of anticoagulation in patients with atrial fibrillation and renal dysfunction: A systematic review2025 · 2 citations
  5. 5The Renal Impact of Direct Oral Anticoagulants versus Vitamin K Antagonists in Patients with Atrial Fibrillation: A Systematic Review and Meta-analysis2026