Single-cell LacNAc sequencing uncovers neutrophil and cytokine involvement in diabetic kidney disease progression, suggesting new therapeutic directions.
Key Points
Increased neutrophil counts and glycosylation patterns were found in patients with type 2 diabetes mellitus and diabetic kidney disease, indicating an immune response.
Functional analysis showed significant enrichment in NET formation pathways, emphasizing the role of neutrophils in disease progression.
Assessment of immune cell populations used single-cell LacNAc sequencing, highlighting low-density granulocytes under hyperglycemic conditions.
Targeting reactive oxygen species and the CXCL8/CXCR2 axis could offer new therapeutic avenues for type 2 diabetic kidney disease.